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| 名称 | 4T1 (小鼠乳腺癌细胞) (STR鉴定正确) |
| 别称 | 4T1-A |
| 种属 | 小鼠 |
| 组织来源 | 乳腺组织 |
| 生长特性 | 贴壁细胞 |
| 细胞形态 | 上皮细胞样 |
| 背景描述 | 4T1细胞是从410.4瘤株中未经诱变筛得的6-硫鸟嘌噙抗性细胞株。当4T1细胞注射到BALB/c小鼠中时，4T1细胞会自发产生高转移肿瘤，可转移到肺、肝、淋巴结和大脑，同时在注射部位形成始发灶，诱导转移时不需要摘除始发灶。4T1细胞在BALB/c小鼠中的生长与转移特性与人体中的乳腺癌十分相近，这种肿瘤是人Ⅵ期乳腺癌的动物模型。4T1细胞诱导的肿瘤在手术后及未手术情况下转移的动力学相近，可以用作手术后及未手术模型。4T1细胞诱导的肿瘤模型跟其他肿瘤模型相比，由于4T1细胞的抗6-硫鸟嘌噙特性，微小的转移细胞团(少到仅仅1个)也可以在许多远端器官中检测到，没必要数淋巴结或称重器官。 |
| 生物安全等级 | 1 |
| 生长培养基 | RPMI-1640(PM150110)＋10% FBS(164210-500)＋1% P/S(PB180120) |
| 推荐传代比例 | 1:3-1:4 |
| 推荐换液频率 | 2~3次/周 |
| 冻存条件 | 冻存液：55% 基础培养基+40%FBS+5%DMSO 温度：液氮 |
| 培养条件 | 气相：空气，95%；CO2，5% 温度：37℃ |
| 致瘤性 | Yes, forms tumors and metastasizes in BALB/c mice. |
| 保藏机构 | ATCC; CRL-2539 |
STR鉴定
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STR位点信息
18-3 18,19 9-2 14.3 6-7 12 5-5 14 X-1 24.3 15-3 22.3 12-1 15.3 6-4 17.3 4-2 19.3 jaridl X -
STR鉴定图
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参考文献
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A photoresponsive and rod-shape nanocarrier: Single wavelength of light triggered photothermal and photodynamic therapy based on AuNRs-capped & Ce6-doped mesoporous silica nanorods(2017.04.01)
作者：Qi Sun, Qing You, Xiaojuan, Pang
期刊：Biomaterials
DOI：10.1016/j.biomaterials.2017.01.021
影响因子 ：10.317
引用产品：CL-0007
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BSA–Bioinspired Gadolinium Hybrid-Functionalized Hollow Gold Nanoshells for NIRF/PA/CT/MR Quadmodal Diagnostic Imaging-Guided Photothermal/Photodynamic Cancer Therapy(2017.10.31)
作者：Qing You, Qi Sun, Meng Yu, Jinping Wang
期刊：ACS Applied Materials & Interfaces
影响因子 ：8.757999999999999
引用产品：CL-0007
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RETURN TO ISSUEPREVRESEARCH ARTICLENEXT Injectable, Biodegradable, Thermosensitive Nanoparticles-Aggregated Hydrogel with Tumor-Specific Targeting, Penetration, and Release for Efficient Postsurgical Prevention of Tumor Recurrence(2019.05.09)
作者：Huiming Liu, Xiaoguang Shi, Di Wu, Frewein Kahsay Khshen
期刊：ACS Appl. Mater. Interfaces
影响因子 ：8.757999999999999
引用产品：CL-0007
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MSOT/CT/MR imaging-guided and hypoxia-maneuvered oxygen self-supply radiotherapy based on one-pot MnO2-mSiO2@Au nanoparticles(2019.03.28)
作者：Siyu Wang, Qing You, Jinping Wang, Yilin Song
期刊：Nanoscale
影响因子 ：6.895
引用产品：CL-0007
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A single-light triggered and dual-imaging guided multifunctional platform for combined photothermal and photodynamic therapy based on TD-controlled and ICG-loaded CuS@mSiO2.(2017.03.01)
作者：Qing You, Qi Sun, Jinping Wang
期刊：Nanoscale
影响因子 ：6.895
引用产品：CL-0007
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A triple-synergistic strategy for combinational photo/radiotherapy and multi-modality imaging based on hyaluronic acid-hybridized polyaniline-coated WS2 nanodots(2017.03.28)
作者：Jinping Wang, Xiaojuan Pang, Xiaoxiao Tan
期刊：Nanoscale
影响因子 ：6.895
引用产品：CL-0007
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Oxygen-rich chemotherapy via modified Abraxane to inhibit the growth and metastasis of triple-negative breast cancer(2018.11.13)
作者：Lingtong Meng, Shaoju Gan, Ya Zhou
期刊：Biomater. Sci.
影响因子 ：6.183
引用产品：CL-0007
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A near-infrared I emissive dye: toward the application of saturable absorber and multiphoton fluorescence microscopy in the deep-tissue imaging window(2019.04.25)
作者：Can Ren, Xiangquan Deng, Wenbo Hu, Junzi Li, Xiaofei Miao
期刊：chemical communications
影响因子 ：5.996
引用产品：CL-0007
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Photosensitizer loaded PEG-MoS₂–Au hybrids for CT/NIRF imaging-guided stepwise photothermal and photodynamic therapy(2017.02.24)
作者：Liu, Li, Wang, Jinping, Tan, Xiaoxiao,
期刊：Journal of materials chemistry B
影响因子 ：5.344
引用产品：CL-0007
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NIRF/PA/CT multi-modality imaging guided combined photothermal and photodynamic therapy based on tumor microenvironment-responsive nanocomposites(2018.06.18)
作者：Li Liu, Jinping Wang, Qing You, Qi Sun, Yilin Song
期刊：Journal of Materials chemistry. B
影响因子 ：5.344
引用产品：CL-0007
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Magnetically-targeted and near infrared fluorescence/magnetic resonance/photoacoustic imaging-guided combinational anti-tumor phototherapy based on polydopamine-capped magnetic Prussian blue nanoparticles(2018.04.06)
作者：Yidan Wang, Xiaojuan Pang, Jinping Wang
期刊：Journal of Materials Chemistry B
影响因子 ：5.344
引用产品：CL-0007
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Free paclitaxel-loaded E-selectin binding peptide modified micelle self-assembled from hyaluronic acid-paclitaxel conjugate inhibit breast cancer metastasis in a murine model(7 August 2017)
作者：Xiaofeng Han, Xuerong Dong, Jing Li, Manyuan Wang
期刊：International Journal of Pharmaceutics
DOI：10.1016/j.ijpharm.2017.05.063
影响因子 ：4.845
引用产品：CL-0007
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Xiaoyao Kangai Jieyu Fang, a Chinese Herbal Formulation, Ameliorates Cancer-Related Depression Concurrent with Breast Cancer in Mice via Promoting Hippocampal Synaptic Plasticity(2018.11.18)
作者：Pan Meng, Yuanshan Han, Qin Yang
期刊：Evidence-Based Complementary and Alternative Medicine
影响因子 ：1.813
引用产品：CL-0007
![Renca [RenCa] (小鼠肾癌细胞) (STR鉴定正确)](/Public/upfile/pic/xbx/CL-0568-1.jpg)
